abstract：PURPOSE:To describe clinical and CT features of L-asparaginase-associated pancreatitis (L-AP) and to correlate CT grades with clinical parameters. METHODS:A total of 16 children (M:F = 9:7; mean age, 8.1 years) who developed L-AP after L-asparaginase (L-asp) treatment and underwent abdominal CT scan were included. We ...

journal_title：Pediatric hematology and oncology

authors： Oh HJ,Im SA,Lee JW,Chung NG,Cho B

更新日期：2014-10-01 00:00:00

abstract：:The endocrinological complications in β-thalassemia major patients do affect the life quality to a large extend. In this study, the endocrinological complications of 47 β-thalassemia patients, who have been followed-up at our hospital's pediatric hematology department, were evaluated. Out of β-thalassemia major cases ...

journal_title：Pediatric hematology and oncology

authors： Isik P,Yarali N,Tavil B,Demirel F,Karacam GB,Sac RU,Fettah A,Ozkasap S,Kara A,Tunc B

更新日期：2014-10-01 00:00:00

abstract：:A 12-year-old female is reported who presented with right hip pain for 6 months. With massive splenohepatomegaly and leukocytosis, CML was suspected and confirmed on bone-marrow examination and cytogenetics. Further investigations confirmed avascular necrosis (AVN) of the right femoral head. CML was treated by hydroxy...

journal_title：Pediatric hematology and oncology

authors： Kumar S,Bansal D,Prakash M,Sharma P

更新日期：2014-09-01 00:00:00

abstract：:Hyperleukocytosis in patients with leukemia is associated with early mortality, especially due to the pulmonary and neurological complications of leukostasis. The prompt use of leukapheresis may improve patients' survival in the initial treatment period. The medical records of all previously untreated acute leukemia p...

journal_title：Pediatric hematology and oncology

authors： Yilmaz D,Karapinar B,Karadaş N,Duyu M,Yazici P,Ay Y,Balkan C,Aydinok Y,Kavakli K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 ...

journal_title：Pediatric hematology and oncology

authors： Honkaniemi E,Mattsson K,Barbany G,Sander B,Gustafsson B

更新日期：2014-05-01 00:00:00

abstract：:The malignant cells of childhood acute lymphoblastic leukemia (ALL) do not form a homogenous entity but a collection of differently maturated blasts. The most immature leukemia cells may be more resistant to therapy than the bulk of more differentiated blasts. We studied 42 patients with childhood ALL treated accordin...

journal_title：Pediatric hematology and oncology

authors： Ahlers J,Witte KE,Schwarze CP,Lang P,Handgretinger R,Ebinger M

更新日期：2014-05-01 00:00:00

abstract：:Outcomes in pediatric B-Non-Hodgkin Lymphoma (B NHL) have improved with intensive chemotherapy protocols, with long-term survival now over 80%. However, long-term adverse effects of therapy and poor outcomes for patients who relapse remain challenges. In this study, we aimed to evaluate the potential risks and benefit...

journal_title：Pediatric hematology and oncology

authors： Eissa HM,Allen CE,Kamdar K,Simko S,Goradia P,Dreyer Z,Steuber P,McClain KL,Guillerman RP,Bollard CM

更新日期：2014-04-01 00:00:00

abstract：:Primary immunodeficiency disorders (PID) are under-reported from the developing world. We present data regarding diagnosis and outcome from a hospital-based registry in India. Forty-seven patients fulfilled diagnostic criteria. Majority were males. Subgroups were disorders of immune dysregulation-29%, B&T-cell abnorma...

journal_title：Pediatric hematology and oncology

authors： Chinnabhandar V,Yadav SP,Kaul D,Verma IC,Sachdeva A

更新日期：2014-04-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal hematological syndrome that causes a disturbance of the immune system. Overall mortality of HLH is greater than 50% and the majority of patients who die do so within the first 8 weeks of chemotherapy treatment. To find clinical parameters relating to high-ri...

journal_title：Pediatric hematology and oncology

authors： Dao AT,Luong VT,Nguyen TT,Huynh QT,Phan TT,Lam MT,Ngoma AM,Koriyama C

更新日期：2014-04-01 00:00:00

abstract：:Acute basophilic leukemia is a distinct entity of Acute Myeloid Leukemia (AML) with primary differentiation to basophils. Increased basophil count has been described in AML cases with translocation t(6;9)(p23;q34) or other chromosomal abnormalities. We describe a 15-year old female teenager with AML and excess periphe...

journal_title：Pediatric hematology and oncology

authors： Servitzoglou M,Grenzelia M,Baka M,Harisi M,Pourtsidis A,Bouhoutsou D,Varvoutsi M,Doganis D,Dana H,Divane A,Kosmidis H

更新日期：2014-03-01 00:00:00

abstract：:The treatment of pediatric severe aplastic anemia (SAA) with allogeneic hematopoietic stem cell transplantation (allo-HSCT), presents major challenges including the risks of graft failure, septic complications, and graft-versus-host disease (GVHD). Additive infusions of human umbilical cord derived mesenchymal stem ce...

journal_title：Pediatric hematology and oncology

authors： Si Y,Yang K,Qin M,Zhang C,Du Z,Zhang X,Liu Y,Yue Y,Feng Z

更新日期：2014-02-01 00:00:00

abstract：UNLABELLED:Intravenous (IV) ferric iron (Fe)-carbohydrate complexes are used for treating Fe deficiency in children with iron-refractory iron-deficiency anemia (IRIDA). An optimal treatment has yet to be determined. There are relatively little publications on the responsiveness to IV iron therapy in children with IRIDA...

journal_title：Pediatric hematology and oncology

authors： Akin M,Atay E,Oztekin O,Karadeniz C,Karakus YT,Yilmaz B,Erdogan F

更新日期：2014-02-01 00:00:00

abstract：:Factor XIII deficiency is a very rare bleeding disorder. We report here on the clinical outcome of a young child with intracranial bleeding due to factor XIII deficiency. Clinicians should bear in mind that severe factor XIII deficiency is associated with a significant risk of unexpected intracranial hemorrhage (ICH)....

journal_title：Pediatric hematology and oncology

authors： Bay A,Sirikci A,Dogan A,Leblebisatan G,Yilmaz F

更新日期：2013-11-01 00:00:00

abstract：UNLABELLED:In settings of limited health resources, using leukocyte-filtered blood is limited to patients with leukocyte-mediated complications. The aim of this study was to determine the patterns of lung dysfunction among patients with β-thalassemia major (BTM) after the application of the leukostop filter during tran...

journal_title：Pediatric hematology and oncology

authors： Hamed Ael S,Ragab IA,Kamel TB,Abd-El-Gawad AO

更新日期：2013-11-01 00:00:00

abstract：:Factor X (FX) is the component of both extrinsic and intrinsic coagulation cascade and is the first enzyme of the common pathway which results in thrombus. Congenital FX deficiency (FXD) is an extremely rare coagulation defect. In this study, we aimed to investigate the clinical and laboratory data of the patients dia...

journal_title：Pediatric hematology and oncology

authors： Karabel M,Söker M,Yıldırım AT,Oymak Y,Kelekçi S,Karabel D

更新日期：2013-11-01 00:00:00

abstract：:The aim of the study is to evaluate the etiologic and clinical characteristics, treatment regimens, and outcome of the patients with intracranial tumors presenting with central diabetes insipidus (DI). Sixty-nine patients with intracranial tumors presenting with central DI between 1972 and 2012 were retrospectively ev...

journal_title：Pediatric hematology and oncology

authors： Varan A,Atas E,Aydın B,Yalçın B,Akyüz C,Kutluk T,Büyükpamukçu M

更新日期：2013-10-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial malignant solid tumors of childhood, and the majority of these high-risk tumors is resistant to nearly all the treatments and has a significantly worse outcome. The mammalian target of rapamycin (mTOR) plays a critical role in oncogenesis and cancer progression of man...

journal_title：Pediatric hematology and oncology

authors： Mei H,Wang Y,Lin Z,Tong Q

更新日期：2013-10-01 00:00:00

abstract：:The third International Conference on Immunotherapy in Pediatric Oncology was held in Frankfurt/Main, Germany, October 1-2, 2012. Major topics of the conference included (i) cellular therapies using antigen-specific and gene-modified T cells for targeting leukemia and pediatric solid tumors; (ii) overcoming hurdles an...

journal_title：Pediatric hematology and oncology

authors： Brehm C,Huenecke S,Pfirrmann V,Rossig C,Mackall CL,Bollard CM,Gottschalk S,Schlegel PG,Klingebiel T,Bader P

更新日期：2013-08-01 00:00:00

abstract：:Few studies have been performed during adolescents' cancer treatment to evaluate its interference on health-related quality of life (HRQL). The purpose of this prospective cohort study was to evaluate adolescents' HRQL during cancer treatment. The Health Utilities Index (HUI) was used for scoring. Forty-five individua...

journal_title：Pediatric hematology and oncology

authors： Rodrigues KE,Machado ST,Ferreira MA,Martins TF,Viana MB,Oliveira BM

更新日期：2013-05-01 00:00:00

abstract：:Although survival rates in childhood cancer have distinctly improved, pediatric cancer patients often experience various disease- and treatment-related side effects with long-term consequences. Despite current studies investigating inactivity and limitations in physical functioning and quality of life in pediatric can...

journal_title：Pediatric hematology and oncology

authors： Beulertz J,Bloch W,Prokop A,Baumann FT

更新日期：2013-05-01 00:00:00

abstract：:Maternal education might be an important factor for the neuroblastoma risk in children, but it was conflicting. This meta-analysis was performed to evaluate the relationship between maternal education and neuroblastoma susceptibility and to explore whether maternal education was an important indicator to be associated...

journal_title：Pediatric hematology and oncology

authors： Wang P,Liao N,Liao XH,Liang B,Huang CX,Li W

更新日期：2013-02-01 00:00:00

abstract：:Medulloblastoma (MB) is a cancer of the cerebellum and the most common primary pediatric malignancy of the central nervous system. Classified as a primitive neural ectoderm tumor; it is thought to arise from granule cell precursors in the cerebellum. The standard of care consists of surgery, chemotherapy and age-depen...

journal_title：Pediatric hematology and oncology

authors： Byrd T,Grossman RG,Ahmed N

更新日期：2012-09-01 00:00:00

abstract：:We present the case of a female newborn with life-threatening bleeding of a ruptured infantile fibrosarcoma (IFS) and consecutive multiorgan dysfunction syndrome shortly after birth. After stabilization, the tumor could be treated without amputation due to surgery, laser therapy, and chemotherapy. The patient is free ...

journal_title：Pediatric hematology and oncology

authors： Kerl K,Nowacki M,Leuschner I,Masjosthusmann K,Frühwald MC

更新日期：2012-09-01 00:00:00

abstract：:A 3-year-old boy presented with recurrent strokes and pallor. Hematological investigations revealed severe iron deficiency anemia without thrombocytosis. The magnetic resonance angiogragraphy findings were suggestive of moyamoya syndrome. The association of moyamoya syndrome with severe iron deficiency anemia has not ...

journal_title：Pediatric hematology and oncology

authors： Meena SS,Ramkumar TV,Sharma S,Aneja S,Kumar A

更新日期：2012-05-01 00:00:00

abstract：:The majority of the anemias during childhood are hypochromic and microcytic. The aim of the present study was to determine the status of α-thalassemia mutations and its association with other etiologies, such as iron deficiency anemia (IDA) and β-thalassemia trait, that are frequently seen hypochromic microcytic anemi...

journal_title：Pediatric hematology and oncology

authors： Gulen H,Hanimeli O,Karaca O,Taneli F

更新日期：2012-04-01 00:00:00

abstract：:Very little has been published on the use of romiplostim to treat primary immune thrombocytopenia (ITP), refractory to previous treatments, in children. The objective of this study was to determine its efficacy and safety in pediatric patients in a university general hospital. Retrospective, longitudinal observational...

journal_title：Pediatric hematology and oncology

authors： Escudero Vilaplana V,Aragonés JH,Fernández-Llamazares CM,Bieler CB,Rodríguez SM,Sáez MS

更新日期：2012-03-01 00:00:00

abstract：:The purpose of this study was to retrospectively analyze the clinical presentation, treatment, and outcomes of children with Wilms tumor (WT) and intravascular extension who were treated at a single institution. A retrospective review was conducted of medical records of all children with Wilms tumor and intravascular ...

journal_title：Pediatric hematology and oncology

authors： Aspiazu D,Fernandez-Pineda I,Cabello R,Ramirez G,Alvarez-Madrid A,De Agustin JC

更新日期：2012-02-01 00:00:00

abstract：:A high (18)F-fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT) imaging in sarcomas of adults has been reported. The current study aimed at defining the degree of (18)F-FDG uptake of pediatric sarcomas. This retrospective study included 29 patients (23 males, 6 females; mean a...

journal_title：Pediatric hematology and oncology

authors： Walter F,Federman N,Apichairuk W,Nelson S,Phelps ME,Allen-Auerbach M,Walter MA,Czernin J

更新日期：2011-10-01 00:00:00

abstract：:Patients with thalassemia intermedia (TI) experience many complications, of which the incidence varies greatly among cases. Considering the high prevalence of thalassemia in Iran, the study was carried out to determine the frequency of TI complications in Iranian patients and to find possible risk factors for each of ...

journal_title：Pediatric hematology and oncology

authors： Rafsanjani KA,Mafi N,Tafreshi RI

更新日期：2011-09-01 00:00:00

abstract：:Overall survival from cancer has greatly improved, although it still remains the second leading cause of mortality in the world. This result was achieved through the use of chemotherapy and radiotherapy, which are severely toxic to normal tissues. In the long-term follow-up of cancer patients, the development of secon...

journal_title：Pediatric hematology and oncology

authors： Varan A,Kebudi R

更新日期：2011-08-01 00:00:00

abstract：:Arsenic trioxide (ATO) has been proven to be highly effective in adults with newly diagnosed or relapsed acute promyelocytic leukemia (APL). Only very limited data are published on the use of ATO as a single agent for first-line therapy of relapsed APL. The authors present a case of a 8-year-old boy with a bone marrow...

journal_title：Pediatric hematology and oncology

authors： Ebinger M,Schwarze CP,Feuchtinger T,Scheel-Walter HG,Lang P,Hildenbrand S,Gessler P,Handgretinger R

更新日期：2011-05-01 00:00:00

abstract：:Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged under or equal to 16 years, admitte...

journal_title：Pediatric hematology and oncology

authors： Akbayram S,Dogan M,Akgun C,Peker E,Parlak M,Caksen H,Oner AF

更新日期：2011-04-01 00:00:00

abstract：:The aim of this retrospective study was to analyze the outcome and identify risk factors associated with progression-free survival (PFS) in 36 children with high-risk neuroblastoma who underwent autologous peripheral blood progenitor cell (PBPC) transplantation between 1994 and 2010. The conditioning regimen used in a...

journal_title：Pediatric hematology and oncology

authors： Molina B,Alonso L,Gonzalez-Vicent M,Andion M,Hernandez C,Lassaletta A,Cormenzana M,Lopez-Ibor B,Villa M,Molina J,Diaz MA

更新日期：2011-03-01 00:00:00

abstract：:Although most common in tropical regions, population migration has meant that sickle cell disease is now one of the most prevalent genetic diseases worldwide. The issues and challenges faced by physicians and patients have been discussed by an international group of experts representing 4 key regions: the USA, Europe,...

journal_title：Pediatric hematology and oncology

authors： Vichinsky EP,Ohene-Frempong K,Thein SL,Lobo CL,Inati A,Thompson AA,Smith-Whitley K,Kwiatkowski JL,Swerdlow PS,Porter JB,Marks PW

更新日期：2011-03-01 00:00:00

abstract：:The percentage of chemotherapy-induced necrosis in primary tumors corresponds with outcome in several childhood malignancies, including high-risk metastatic diseases. In this retrospective pilot study, the authors assessed the importance of postchemotherapy necrosis in high-risk neuroblastoma with a histological and c...

journal_title：Pediatric hematology and oncology

authors： Bomken S,Davies B,Chong L,Cole M,Wood KM,McDermott M,Tweddle DA

更新日期：2011-03-01 00:00:00

abstract：:There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with β-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern...

journal_title：Pediatric hematology and oncology

authors： Bazrgar M,Peiravian F,Abedpour F,Karimi M

更新日期：2011-03-01 00:00:00

abstract：:Olfactory neuroblastoma, a rare malignancy of the olfactory epithelium, is an uncommon tumor in children. It occurs mostly in older individuals and the treatment strategies are based on the experience with adults. In this report, clinical characteristics and treatment results of 2 patients with olfactory neuroblastoma...

journal_title：Pediatric hematology and oncology

authors： Küpeli S,Yalçin B,Büyükpamukçu M

更新日期：2011-02-01 00:00:00

abstract：:Between 1983 and 2008, prenatal diagnostic procedures for identifying hemoglobinopathies were performed in 947 at-risk fetuses. Seventy-six percent of the fetuses were at risk for β-thalassemia major and 16% for sickle cell anemia; only a small percentage (7%) were at risk for compound heterozygosity of β-thalassemia ...

journal_title：Pediatric hematology and oncology

authors： Beksac MS,Gumruk F,Gurgey A,Cakar N,Mumusoglu S,Ozyuncu O,Altay C

更新日期：2011-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to play a central role in angiogenesis-lymphangiogenesis in hematological malignancies. There are limited data related to childhood hematologic malignancies. The aim of the study was to evaluate soluble VEGF (sVEGF) levels in children with acute leukemia and malignant ly...

journal_title：Pediatric hematology and oncology

authors： Dincaslan HU,Yavuz G,Unal E,Tacyildiz N,Ikinciogullari A,Dogu F,Guloglu D,Yuksek N,Ertem U

更新日期：2010-10-01 00:00:00

abstract：:The acquired form of pure red cell aplasia (PRCA) presents either as an acute self-limited disease, predominantly seen in children, or as a chronic illness more frequently seen in adults with rare spontaneous remissions. A 14-year-old boy presented with pallor, without hepatosplenomegaly, jaundice, lymphadenopathy, pe...

journal_title：Pediatric hematology and oncology

authors： Khalil A,Elhasid R,Ben Barak A,Ben Arush MW

更新日期：2010-10-01 00:00:00